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Pediatr Blood Cancer. 2006 Jan;46(1):94-8.

Alternative medicine remedies might stimulate viability of leukemic cells.

Author information

1
Department of Pediatric Hematology and Oncology, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University of Torun, Bydgoszcz, Poland. jstyczynski@cm.umk.pl

Abstract

OBJECTIVE:

Ex vivo activity of three products of alternative therapy against leukemic and normal cells was analyzed.

MATERIAL AND METHODS:

Extracts of Viscum album, Uncaria tomentosa, and Croton lechleri were used for the study. Leukemic cells of 53 children with acute leukemias and four cell lines, Jurkat, CCRF-CEM, HL-60, and K-562 were tested for sensitivity to alternative medicine remedies by the MTT assay, cell-cycle analysis and annexin-V binding assay.

RESULTS:

Leukemic cells showed high resistance to tested three compounds of alternative medicine in all performed assays. Additionally, tested remedies stimulated survival of leukemic cells in 45%, 96%, and 83% cases, respectively; while no effect was observed in normal lymphocytes. In combination studies, Viscum album extract did not increase prednisolone and cytarabine cytotoxicity in leukemic cells.

CONCLUSION:

We conclude that some alternative medicine remedies might stimulate the viability of childhood leukemic cells.

PMID:
16047362
DOI:
10.1002/pbc.20513
[Indexed for MEDLINE]

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