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Behav Brain Res. 2005 Oct 14;164(1):132-6.

Sexual dimorphism in the vasopressin system: lack of an altered behavioral phenotype in female V1a receptor knockout mice.

Author information

1
Department of Psychiatry, Emory University, Atlanta, GA 30329, USA. alanwithisa@yahoo.com

Abstract

Previous findings with an AVP V1a receptor knockout mouse (V1aRKO) demonstrate a significant role for this receptor in anxiety-like behavior in males. Here we report the lack of anxiety-like effects of the null mutation in female mice. V1aRKO females performed normally on all tests for anxiety-like behavior. This sex difference may be due to the sexual dimorphism in the extra-hypothalamic vasopressin system, with males having significantly more vasopressin fibers in this system.

PMID:
16046007
DOI:
10.1016/j.bbr.2005.06.005
[Indexed for MEDLINE]

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