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J Pak Med Assoc. 2005 Jun;55(6):245-7.

Frequency of thrombophilia in patients with adverse pregnancy outcome.

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1
Department of Obstetrics and Gynaecology, Unit 2, Civil Hospital, Karachi.

Abstract

OBJECTIVE:

To determine the association between adverse pregnancy outcomes and thrombophilia.

METHODS:

This is a descriptive study, incorporating retrospective analysis of patients with recurrent pregnancy losses, intrauterine deaths, abruptio placenta and early onset pre eclampsia. Patients with adverse pregnancy outcomes in whom co-morbid factors were excluded underwent screening for both acquired and inherited thrombophilia.

RESULTS:

A total of 40 patients were screened for acquired and inherited thrombophilia with adverse pregnancy outcomes. Anticardiolipin antibodies were found positive in 55% of patients and 45% of patients were found deficient for natural anticoagulants protein C and S. Two patients were found positive for both acquired and inherited thrombophilia.

CONCLUSION:

Thrombophilia, both acquired and inherited are associated with adverse pregnancy outcomes. Patients in whom other co-morbid factors are excluded, should be offered screening for thrombophilia. Liaison between hematologist and obstetrician is the corner stone for success.

PMID:
16045094
[Indexed for MEDLINE]
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