Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Hematol. 2005 Aug;79(4):334-6.

Large granular lymphocytic proliferation-associated cyclic thrombocytopenia.

Author information

1
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. pfogarty@medicine.ucsf.edu

Abstract

Cyclic thrombocytopenia is a rare condition characterized by regular fluctuations in the platelet count, resulting in bleeding at the time of platelet count nadir. We evaluated a male patient whose platelet count cycled between <10x10(9)/L and a maximum of >1300x10(9)/L over a median of every 42 days (range, 28-57 days). Antiplatelet antibodies were present at highest titer just prior to platelet nadirs. A pathologic expansion of CD3+CD57+ large granular lymphocytes (LGLs) along with a clonal rearrangement of the T-cell receptor (TCR) gamma gene in circulating T cells was detected. LGLs decreased in response to treatment with cyclosporine-A (CsA), but the cycling of the platelet count continued. This is the first report of cyclic thrombocytopenia associated with a T-LGL lymphoproliferative disorder.

PMID:
16044437
DOI:
10.1002/ajh.20375
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center