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Neurology. 2005 Jul 26;65(2):317-9.

Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms.

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UCLA-Geffen School of Medicine, Los Angeles, CA, USA.


Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.

[Indexed for MEDLINE]

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