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Neurology. 2005 Jul 26;65(2):293-5.

The smoking-thrombolysis paradox and acute ischemic stroke.

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Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA.


Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.

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