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Infect Immun. 2005 Aug;73(8):5252-5.

Infectivity of Cryptosporidium hominis and Cryptosporidium parvum genotype 2 isolates in immunosuppressed Mongolian gerbils.

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  • 1Laboratoire d'Immunologie et d'Immunopathologie, CHU Clemenceau, 14033 Caen Cedex, France.

Abstract

One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10(5) oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.

PMID:
16041051
PMCID:
PMC1201256
DOI:
10.1128/IAI.73.8.5252-5255.2005
[PubMed - indexed for MEDLINE]
Free PMC Article
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