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Infect Immun. 2005 Aug;73(8):5249-51.

Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.

Author information

1
Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. cc30r@clinmed.gla.ac.uk

Abstract

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

PMID:
16041050
PMCID:
PMC1201246
DOI:
10.1128/IAI.73.8.5249-5251.2005
[Indexed for MEDLINE]
Free PMC Article

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