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Infect Immun. 2005 Aug;73(8):5183-8.

Probiotics reduce enterohemorrhagic Escherichia coli O157:H7- and enteropathogenic E. coli O127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements.

Author information

1
Gastroenterology and Nutrition, Room 8409, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. sherman@sickkids.ca

Abstract

The aim of this study was to determine if probiotics reduce epithelial injury following exposure to Escherichia coli O157:H7 and E. coli O127:H6. The pretreatment of intestinal (T84) cells with lactic acid-producing bacteria reduced the pathogen-induced drop in transepithelial electrical resistance. These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria.

PMID:
16041036
PMCID:
PMC1201237
DOI:
10.1128/IAI.73.8.5183-5188.2005
[Indexed for MEDLINE]
Free PMC Article

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