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Cancer Lett. 2005 Aug 26;226(2):155-60. Epub 2004 Dec 16.

pp32/ I-1(PP2A) negatively regulates the Raf-1/MEK/ERK pathway.

Author information

1
Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan.

Abstract

In this study, we focus on the potential interaction of pp32/I-1(PP2A) (pp32) with the Raf-MEK-ERK signaling pathway. We show that overexpressed pp32 suppresses Raf-1 activation, thereby downregulating the level of ERK activation. This suppression of Raf-1 requires the C-terminal half of pp32. Conversely, knock-down of PP32 by siRNA enhances ERK and MEK activations. Taken together, we propose that tumor-suppression by pp32 is, at least in part, mediated by downregulation of the Raf-MEK-ERK signaling pathway.

PMID:
16039954
DOI:
10.1016/j.canlet.2004.11.026
[Indexed for MEDLINE]

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