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Immunity. 2005 Jul;23(1):1-2.

Divide and conquer: division of labor by B-1 B cells.

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1
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.

Abstract

Capsular polysaccharides enhance bacterial virulence. In this issue of Immunity, demonstrate a division of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by Streptococcus pneumoniae, whereas B-1b cells generate the anticapsule-induced response that prevents fatal infection.

PMID:
16039572
DOI:
10.1016/j.immuni.2005.07.001
[Indexed for MEDLINE]
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