Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 2005 Sep;30(9):479-83.

Vitamin B3 and sirtuin function.

Author information

1
University of Wisconsin Medical School, Department of Biomolecular Chemistry, 1300 University Avenue, Madison, WI 53706, USA. jmdenu@wisc.edu

Abstract

Sirtuins are NAD(+)-dependent protein deacetylases that are involved in transcriptional regulation, metabolism, apoptosis, differentiation and ageing. These unique enzymes are inhibited by nicotinamide, which is a form of vitamin B3. Recent studies have uncovered the molecular basis for nicotinamide inhibition, and provided the framework to understand the physiological processes mediated by sirtuins and to develop strategies to modulate their cellular activity.

PMID:
16039130
DOI:
10.1016/j.tibs.2005.07.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center