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EMBO J. 2005 Aug 3;24(15):2715-9. Epub 2005 Jul 21.

Deconstructing stemness.

Author information

1
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden.

Abstract

Stem cells are unique in their capacity to self-renew and generate differentiated progeny to maintain tissues throughout life. A common molecular program for stem cells has remained elusive. We discuss what the molecular logic of stemness may be. We suggest that it may not be coupled to distinct cellular properties such as self-renewal or multipotency, but rather to the stable suspension at a specific developmental stage. In this view, the stem cell niche allows a cell to maintain a transcriptional accessibility enabling the generation of specific differentiated progeny.

PMID:
16037819
PMCID:
PMC1182244
DOI:
10.1038/sj.emboj.7600749
[Indexed for MEDLINE]
Free PMC Article

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