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Curr Diab Rep. 2005 Aug;5(4):254-9.

Adiponectin: protection of the endothelium.

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1
Department of Medicine and Research Centre of Heart, Brain, Hormone & Healthy Aging, Medical Faculty, University of Hong Kong, 21, Pokfulam, Hong Kong. ksllam@hkucc.hku.hk

Abstract

Low levels of adiponectin, a fat-derived hormone, are found in coronary heart disease, type 2 diabetes, obesity, and other insulin-resistant states. Conversely, high adiponectin levels are predictive of reduced coronary risk in long-term epidemiologic studies. A close association between hypoadiponectinemia and endothelial dysfunction has also been demonstrated. The various mechanisms through which adiponectin may protect the endothelium, via its insulin-sensitizing, antiatherogenic, anti-inflammatory, and antioxidant properties, are reviewed.

PMID:
16033674
[Indexed for MEDLINE]
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