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Int J Clin Exp Hypn. 2005 Apr;53(2):170-97.

Control conditions in hypnotic-analgesia clinical trials: challenges and recommendations.

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Department of Rehabilitation Medicine, Box 356490, University of Washington, Seattle, WA 98195-6490, USA.


Case studies and controlled clinical trials indicate that hypnotic analgesia can effectively reduce pain in patients with a number of different chronic pain conditions. However, because none of the studies published to date have included a credible control condition that adequately controls for expectancy effects, at this point we cannot conclude that hypnotic-analgesia treatment has a specific effect on chronic pain beyond that that might be produced by a credible placebo intervention. This paper (a) describes the types of control conditions that have been, or might be, used in clinical trials of hypnotic analgesia for chronic pain; (b) reviews their strengths and weaknesses; and (c) concludes with specific recommendations that investigators should consider when designing clinical trials of hypnotic analgesia.

[Indexed for MEDLINE]

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