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Eur J Immunol. 2005 Aug;35(8):2416-23.

TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1.

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University of Sussex, Infection and Immunity group, School of Life Sciences, Brighton, UK.


Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.

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