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Nat Neurosci. 2005 Aug;8(8):1022-7. Epub 2005 Jul 17.

Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA.

Abstract

In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.

PMID:
16025107
PMCID:
PMC1352169
DOI:
10.1038/nn1508
[Indexed for MEDLINE]
Free PMC Article

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