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Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63.

Mitochondrial fission in apoptosis.

Author information

1
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. youler@ninds.nih.gov

Abstract

Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.

PMID:
16025099
DOI:
10.1038/nrm1697
[Indexed for MEDLINE]

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