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Physiology (Bethesda). 2005 Aug;20:252-9.

Genomes optimize reproduction: aging as a consequence of the developmental program.

Author information

1
Department of Genetics, Harvard Medical School, Boston, MA, USA. jp@senescence.info

Abstract

Natural selection shapes genomes for reproduction, not for postreproductive survival. One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive deterioration of physiological function that we call aging are also discussed.

PMID:
16024513
DOI:
10.1152/physiol.00010.2005
[Indexed for MEDLINE]
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