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Trends Genet. 2005 Sep;21(9):477-80.

Getting a molecular grasp on Hox contextual activity.

Author information

1
Laboratoire de Génétique et Physiologie du Développement, IBDM, CNRS, Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France.

Abstract

Hox genes encode evolutionarily conserved transcription factors with key functions in development and evolution. Although the multitude of processes individually controlled by Hox proteins highlights the importance of contextual information in setting their diverse activities, the underlying molecular mechanisms still remain elusive. A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information.

PMID:
16023254
DOI:
10.1016/j.tig.2005.07.001
[Indexed for MEDLINE]

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