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J Cosmet Laser Ther. 2004 Dec;6(4):223-6.

Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler.

Author information

1
Skin Laser and Surgery Specialists of NY/NJ, Hackensack, NJ 07601, USA.

Abstract

BACKGROUND:

Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers.

OBJECTIVE:

We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection.

METHODS:

Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3-mm punch tissue biopsy was taken at 1 and 6 months post-injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated.

RESULTS:

CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time.

CONCLUSION:

This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.

PMID:
16020207
DOI:
10.1080/147641704100003048
[Indexed for MEDLINE]

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