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J Paediatr Child Health. 2005 Jul;41(7):382-3.

Antibiotic-related renal failure and cystic fibrosis.

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1
Department of Nephrology, Sydney Children's Hospital, New South Wales, Australia. kennedys@sesahs.nsw.gov.au

Abstract

Recently published reports suggest that the combination of aminoglycosides with ceftazidime may increase the risk of renal disease in cystic fibrosis. We describe a case of unusually severe acute tubular necrosis occurring in an adolescent with cystic fibrosis receiving i.v. gentamicin plus ceftazidime and discuss the possible mechanisms.

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