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J Paediatr Child Health. 2005 Jul;41(7):382-3.

Antibiotic-related renal failure and cystic fibrosis.

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Department of Nephrology, Sydney Children's Hospital, New South Wales, Australia.


Recently published reports suggest that the combination of aminoglycosides with ceftazidime may increase the risk of renal disease in cystic fibrosis. We describe a case of unusually severe acute tubular necrosis occurring in an adolescent with cystic fibrosis receiving i.v. gentamicin plus ceftazidime and discuss the possible mechanisms.

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