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FEMS Microbiol Lett. 1992 Apr 15;71(2):163-8.

Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus.

Author information

1
Laboratoire de mycologie, Centre hospitalier universitaire vaudois, Lausanne, Switzerland.

Abstract

An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.

PMID:
1601287
DOI:
10.1016/0378-1097(92)90506-j
[Indexed for MEDLINE]

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