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Nat Rev Genet. 2005 Aug;6(8):648-54.

Silence of the genes--mechanisms of long-term repression.

Author information

1
Department of Cellular Biochemistry and Human Genetics, Hebrew University Medical School, Ein Kerem, Jerusalem, Israel.

Abstract

A large fraction of genes in the mammalian genome is repressed in every cell throughout development. Here, we propose that this long-term silencing is carried out by distinct molecular mechanisms that operate in a global manner and, once established, can be maintained autonomously through DNA replication. Both individually and in combination these mechanisms bring about repression, mainly by lowering gene accessibility through closed chromatin structures.

PMID:
16012529
DOI:
10.1038/nrg1639
[Indexed for MEDLINE]
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