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Br J Cancer. 2005 Jul 25;93(2):173-7.

Potential for improvement of docetaxel-based chemotherapy: a pharmacological review.

Author information

1
Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. f.engels@erasmusmc.nl

Abstract

Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.

PMID:
16012521
PMCID:
PMC2361544
DOI:
10.1038/sj.bjc.6602698
[Indexed for MEDLINE]
Free PMC Article

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