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J Oral Pathol Med. 2005 Aug;34(7):423-5.

Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.

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Stomatology Clinic, II University of Medicines and Surgery, Naples, Italy.



The objective of this study was to investigate the effect of zinc on recurrent herpes labialis.


Twenty patients (12 females; median age 26.6 years) with a history of recurrent herpes labialis >6 episodes each year were treated with systemic zinc sulphate 22.5 mg twice daily for the months of February, March, September and October. All patients were followed for 12 months.


Herpetic lesions reduced to <4 episodes (average 3) for the 12 months and the duration was <7 days for each episode (average 5.7).


Systemic zinc sulphate appeared to reduce both the number of episodes and the time to recovery of herpes labialis.

[Indexed for MEDLINE]

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