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Neurology. 2005 Jul 12;65(1):147-9.

Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.

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Department of Neurology, University Hospital, Z├╝rich, Switzerland.


Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.

[Indexed for MEDLINE]

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