Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2005 Sep;21(9):526-32.

Computational genetics: from mouse to human?

Author information

1
Department of Genetics and Genomics, Roche Palo Alto S3-1, Palo Alto, CA 94304, USA.

Abstract

In this article, we describe a novel computational-analysis method that rapidly identified the genetic basis for several trait differences among inbred mouse strains. This approach enables researchers to identify a causative genetic factor by correlating a pattern of observable physiological or pathological differences among selected inbred strains with a pattern of genetic variation. Compared with conventional methods used for mouse genetic analysis, which require many years to produce results, this haplotype-based computational analysis can be rapidly performed. We discuss the factors affecting the performance and precision of this computational method. Although it currently can analyze traits of limited genetic complexity in mouse, the potential application of this genetic-analysis method to other experimental organisms, and possibly humans, is evaluated.

PMID:
16009447
DOI:
10.1016/j.tig.2005.06.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center