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Clin Biochem. 2005 Oct;38(10):900-4.

Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein.

Author information

1
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA. oglesbee.1@osu.edu

Abstract

OBJECTIVES:

Diabetic ketoacidosis (DKA) represents a metabolic stress whose treatment induces a systemic proinflammatory cytokine profile and accentuates life-threatening acute complications. The present study determined whether serum levels of the major inducible 70-kDa heat shock protein (Hsp72), a modulator of cytokine expression, were influenced by DKA and its treatment.

DESIGN AND METHODS:

Serum levels of Hsp72 and glucose were measured in five adolescents with type 1 diabetes mellitus (T1DM) prior to, during and following correction of severe DKA. Samples from nine relatively euglycemic T1DM patients served as controls.

RESULTS:

DKA pre-treatment samples showed significant elevation in Hsp72 (40.8 +/- 6.9 ng/ml) relative to euglycemic T1DM controls (33.6 +/- 3.2 ng/ml) (P < 0.05). Treatment resulted in a decline in Hsp72 to control levels within 24 h, with Hsp72 and glucose levels being tightly correlated (r = 0.9258).

CONCLUSION:

Extracellular Hsp72 is increased by DKA, paralleling changes in serum glucose levels.

[Indexed for MEDLINE]

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