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Clin Biochem. 2005 Jul;38(7):674-7.

Non protein bound iron concentrations in amniotic fluid.

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1
Department Paediatrics G. Gaslini, Children's University Hospital, 16148 Genoa, Italy.

Abstract

OBJECTIVES:

To investigate whether amniotic fluid concentrations of non protein bound iron (NPBI) vary with growth in healthy fetuses and also offer a reference curve in the second trimester of pregnancy.

DESIGN AND METHODS:

Amniotic fluid concentrations of NPBI were measured by HPLC in 118 women with physiological singleton pregnancies, who underwent amniocentesis for fetal karyotype between weeks 15 and 18 of gestation.

RESULTS:

NPBI increased progressively from weeks 14--15 to weeks 15--16, peaking at 17--18 weeks of gestation. NPBI values regressed positively with gestational age (GA). Multiple linear regression analysis between NPBI, as dependent variable, and various fetal parameters, as independent variables, showed a statistically significant regression coefficient with GA, bi-parietal diameter and transverse cerebellar diameter.

CONCLUSIONS:

The present data constitutes the first quantification of NPBI concentrations in amniotic fluid under physiological conditions. Correlations with GA and ultrasound fetal biometry suggest that NPBI may play a role in fetal growth.

[Indexed for MEDLINE]

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