Format

Send to

Choose Destination
Cell. 2005 Jul 15;122(1):13-6.

The role of the RNAi machinery in heterochromatin formation.

Author information

1
RLP-AgroScience GmbH, AlPlanta-Institute for Plant Research, Breitenweg 71, 67435 Neustadt, Germany. michael.wassenegger@agroscience.rlp.de

Abstract

Considerable effort has been devoted to the characterization of RNA interference (RNAi), a posttranscriptional gene silencing mechanism involving small RNA-containing effector complexes. Recent studies have revealed that components of the RNAi machinery are associated not only with target RNA cleavage and impairment of target RNA translation but also with the formation of heterochromatin. There is increasing evidence that RNA-mediated chromatin modifications play an important role in epigenetic transcriptional gene silencing.

PMID:
16009128
DOI:
10.1016/j.cell.2005.06.034
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center