Format

Send to

Choose Destination
Am J Vet Res. 2005 Jun;66(6):1090-3.

Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole.

Author information

1
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.

Abstract

OBJECTIVE:

To evaluate and compare the in vitro antifungal properties of lufenuron and nikkomycin Z against isolates of Coccidioides immitis and Aspergillus fumigatus when used singly and in combination with the azole antifungal agent itraconazole.

SAMPLE POPULATION:

3 clinical isolates of A fumigatus and the Silveira strain of C immitis.

PROCEDURE:

The fungal isolates were tested in vitro for susceptibility to the single and combination of compounds by use of microtiter-format susceptibility methods. Minimum inhibitory concentration end points were determined visually, and the contents of representative wells were examined microscopically for evidence of morphologic effects on fungi.

RESULTS:

No evidence of inhibition, either by susceptibility testing or direct microscopic examination of treated cells, was obtained with lufenuron under experimental conditions. In contrast, nikkomycin Z, a known inhibitor of fungal chitin synthesis, had potent activity against C immitis when used singly. A synergistic interaction between nikkomycin Z and itraconazole was found against isolates of both species tested.

CONCLUSIONS AND CLINICAL RELEVANCE:

On the basis of our in vitro data, lufenuron does not appear to possess antifungal properties.

PMID:
16008236
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center