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Clin Infect Dis. 2005 Aug 1;41(3):e27-8. Epub 2005 Jun 28.

Subtherapeutic ocular penetration of caspofungin and associated treatment failure in Candida albicans endophthalmitis.

Author information

1
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Abstract

Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration.

PMID:
16007519
DOI:
10.1086/431761
[Indexed for MEDLINE]

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