Format

Send to

Choose Destination
Nat Neurosci. 2005 Aug;8(8):985-7. Epub 2005 Jul 10.

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1.

Author information

1
Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University, Baltimore, Maryland 21205, USA.

Abstract

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

PMID:
16007085
DOI:
10.1038/nn1432
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center