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Nat Neurosci. 2005 Aug;8(8):988-90. Epub 2005 Jul 10.

Cortical calcium waves in resting newborn mice.

Author information

1
Physiologisches Institut, Ludwig-Maximilians Universität München, Pettenkoferstr. 12, 80336 München, Germany.

Abstract

Using a new optical fiber-based approach, we demonstrate the presence of recurrent Ca(2+) transients in cortical neurons of non-anesthetized newborn mice in vivo. These Ca(2+) waves reflect the correlated activity of thousands of cells and were detected only in resting, but not in moving pups. Our results suggest that Ca(2+)-dependent cortical maturation occurs predominantly during the intermittent sleep-like resting periods that are characteristic for the first days of postnatal life.

PMID:
16007081
DOI:
10.1038/nn1502
[Indexed for MEDLINE]

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