Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2005 Sep 15;15(18):4068-72.

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.

Author information

1
Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA. sgovek@san.rr.com

Abstract

Metabotropic glutamate receptor 2 (mGluR2) has been implicated in a variety of CNS disorders, including schizophrenia. Disclosed herein is the development of a new series of allosteric potentiators of mGluR2. Structure-activity relationship studies in conjunction with pharmacokinetic data led to the discovery of indole 5, which is active in an animal model for schizophrenia.

PMID:
16005222
DOI:
10.1016/j.bmcl.2005.06.017
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center