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Antivir Chem Chemother. 2005;16(3):169-82.

Retrovirus reverse transcriptases containing a modified YXDD motif.

Author information

1
Laboratory of Biochemical Pharmacology and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Abstract

The YXDD motif, where X is a variable amino acid, is highly conserved among various viral RNA-dependent DNA polymerases. Mutations in the YXDD motif can abolish enzymatic activity, alter the processivity and fidelity of enzymes and decrease virus infectivity. This review provides a summary of the significant documented studies on the YXDD motif of HIV-1, simian immunodeficiency virus, feline immunodeficiency virus and murine leukaemia virus and the impact of mutation that this motif has had on viral pathogenesis and drug treatment.

PMID:
16004080
DOI:
10.1177/095632020501600303
[Indexed for MEDLINE]

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