Format

Send to

Choose Destination
Skeletal Radiol. 2005 Oct;34(10):625-31. Epub 2005 Jul 8.

Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.

Author information

1
Department of Radiology, University of Medicine and Dentistry C320, University Hospital, 150 Bergen St., Newark, NJ, 07103-2426, USA. blacksin@umdnj.edu

Abstract

OBJECTIVE:

The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.

DESIGN AND PATIENTS:

A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done. The images were reviewed by two musculoskeletal radiologists in a consensus fashion. Lesion location, size, shape, margination, and signal intensity characteristics were assessed. MR findings were correlated with histopathological examination.

RESULTS:

The benign subtype of GrCT is usually isointense or brighter than muscle on T1-weighted sequences, round or oval in shape, superficial in location, and 4 cm or less in size. On T2-weighted sequences, benign lesions may demonstrate a high peripheral signal, as well as a central signal intensity that is isointense to muscle or suppressed fat. A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences. The malignant subtype may demonstrate signal intensity characteristics and invasion of adjacent structures often seen with other aggressive neoplasms; sizes larger than 4 cm and association with major nerve trunks can be seen.

CONCLUSION:

Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.

PMID:
16003548
DOI:
10.1007/s00256-005-0925-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center