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Appl Bioinformatics. 2005;4(1):71-4.

BioLayout(Java): versatile network visualisation of structural and functional relationships.

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Computational Genomics Group, European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, UK.


Visualisation of biological networks is becoming a common task for the analysis of high-throughput data. These networks correspond to a wide variety of biological relationships, such as sequence similarity, metabolic pathways, gene regulatory cascades and protein interactions. We present a general approach for the representation and analysis of networks of variable type, size and complexity. The application is based on the original BioLayout program (C-language implementation of the Fruchterman-Rheingold layout algorithm), entirely re-written in Java to guarantee portability across platforms. BioLayout(Java) provides broader functionality, various analysis techniques, extensions for better visualisation and a new user interface. Examples of analysis of biological networks using BioLayout(Java) are presented.

[Indexed for MEDLINE]

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