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Trends Endocrinol Metab. 2005 Aug;16(6):261-6.

Vitamin D and type 1 diabetes mellitus: state of the art.

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1
Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium. chantal.mathieu@med.kuleuven.ac.be

Abstract

Recent evidence suggests a role for vitamin D in pathogenesis and prevention of diabetes mellitus. Active vitamin D, 1alpha,25(OH)(2)D(3), prevents type 1 diabetes in animal models, modifies T-cell differentiation, modulates dendritic cell action and induces cytokine secretion, shifting the balance to regulatory T cells. High-dose vitamin D supplementation early in life protects against type 1 diabetes. 1alpha,25(OH)(2)D(3) activity is mediated through its receptor, and targets include transcriptional regulators; therefore, 1alpha,25(OH)(2)D(3) influences gene transcription. 1alpha,25(OH)(2)D(3) also affects pancreatic beta-cell function. Genomic variations of vitamin D metabolism and target cell action predispose to type 1 diabetes. Vitamin D deficiency in pregnancy probably increases the incidence of autoimmune diseases, such as type 1 diabetes, in genetically predisposed individuals. Pharmacotherapy with 1alpha,25(OH)(2)D(3) analogues might help prevent and treat diabetes.

PMID:
15996876
DOI:
10.1016/j.tem.2005.06.004
[Indexed for MEDLINE]
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