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Am J Transplant. 2005 Aug;5(8):1789-92.

Granulysin: a novel host defense molecule.

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Department of Pediatrics, Stanford University, Stanford, CA, USA.


Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

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