Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2005 Aug 1;192(3):537-44. Epub 2005 Jul 1.

Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice.

Author information

1
Laboratory of Neurobiologie Integrative, Formation de Recherche en Evolution 2723 Centre National de la Recherche Scientifique-Unite Mixte de Recherche 1244 Institut National de Recherche Agronomique, Institut Francois Magendie, Bordeaux, France.

Abstract

BACKGROUND:

Activation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link in the relationship between cytokines and depression. We aimed to develop an experimental model of chronic IDO activation based on bacille Calmette-Guérin (BCG) infection that elicits a robust increase in levels of interferon (IFN)- gamma, a key cytokine in the activation of IDO.

METHODS:

Mice were inoculated intraperitoneally with BCG (10(7) cfu/mouse). Lung and brain IDO activity was measured over time, together with plasma levels of TRP and IFN- gamma.

RESULTS:

BCG induced, over the course of several weeks, a chronic increase in serum IFN- gamma levels that was associated with a sustained enhancement of lung and brain IDO activity and with decreases in peripheral (serum and lungs) and brain concentrations of TRP, with different time courses between tissues.

CONCLUSIONS:

The model of BCG-induced IDO activation will be useful for the study of the consequences of peripheral immune activation in the brain and the role of TRP metabolism in cytokine-induced mood alteration.

PMID:
15995970
DOI:
10.1086/431603
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center