Format

Send to

Choose Destination
Arthritis Rheum. 1992 Jun;35(6):611-4.

Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis.

Author information

1
Department of Clinical Pharmacology, University of Berne, Switzerland.

Abstract

OBJECTIVE:

To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis.

METHODS:

Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to evaluate drug levels.

RESULTS:

Food reduced the peak concentration, from a mean of 0.71 mumoles/liter to 0.49 mumoles/liter (P less than 0.02), and slightly increased the time to peak concentration, from a mean of 1.3 hours to 2.0 hours. Bioavailability was highly variable (range 28-94%) but was not affected by food intake.

CONCLUSION:

Bioavailability of oral methotrexate shows marked interindividual variation but is not affected by the presence of food.

PMID:
1599518
DOI:
10.1002/art.1780350603
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center