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Mech Ageing Dev. 2005 Oct;126(10):1130-3.

Cellular replicative capacity correlates primarily with species body mass not longevity.

Author information

1
The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA.

Abstract

Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.

PMID:
15993927
DOI:
10.1016/j.mad.2005.05.004
[Indexed for MEDLINE]

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