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Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes.

Author information

1
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India.

Abstract

Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.4] and hyaluronidase [E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated.

PMID:
15993585
DOI:
10.1016/j.bmcl.2005.06.012
[Indexed for MEDLINE]

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