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Bioorg Med Chem Lett. 2005 Sep 1;15(17):3900-7.

Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.

Author information

1
BAYER HealthCare AG, Business Group Pharma, D-42096 Wuppertal, Germany. helmut.Haning@bayerhealthcare.com

Abstract

Several different heterocyclic systems were compared as PDE5 inhibitor scaffolds. In addition to the known 3H-imidazo[5,1-f][1,2,4]triazin-4-ones and pyrazolopyrimidinones, isomeric imidazo[1,5-a][1,3,5]triazin-4(3H)-ones were also shown to be potent and selective PDE inhibitor scaffolds with in vivo activity. SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds.

PMID:
15993055
DOI:
10.1016/j.bmcl.2005.05.090
[Indexed for MEDLINE]

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