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Curr Opin Struct Biol. 2005 Aug;15(4):435-40.

Sane in the membrane: designing systems to modulate membrane proteins.

Author information

1
Department of Biochemistry, University Walk, University of Bristol, Bristol BS8 1TD, UK. paula.booth@bristol.ac.uk

Abstract

Proteins and lipids make sense in rational approaches to the design of systems for the study of membrane proteins. Lipids surround integral membrane proteins in their natural environment. Although lipids have always formed part of investigations into membrane proteins, it has generally been the proteins themselves that have taken the limelight. As knowledge of membrane proteins has increased, so has that of their interactions with lipids. This increased understanding of the interplay of proteins and lipids, together with existing knowledge of lipid properties, is enabling new approaches to be introduced for membrane protein study. The lipids can be used to control protein behaviour and as novel probes of protein motion.

PMID:
15993047
DOI:
10.1016/j.sbi.2005.06.002
[Indexed for MEDLINE]

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