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Cytokine Growth Factor Rev. 2005 Dec;16(6):625-36. Epub 2005 Jun 28.

Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention.

Author information

1
Celltech, 216 Bath Road, Slough, Berkshire, UK. zoe.johnson@slh.celltechgroup.com

Abstract

Despite their key role in inflammation, the apparent redundancy in the chemokine system is often cited as an argument against probing chemokines as therapeutic targets for inflammation. However, this in vitro redundancy frequently does not translate to the in vivo situation, as exemplified by the use of specific receptor antagonists, ligand neutralizing or receptor blocking antibodies and gene-deleted mice in models of human disease. Specificity may be conferred onto the chemokine system by fine-tuning of responses both temporally and spatially through their highly specific interactions with glycosaminoglycans (GAGs). In this survey, we present evidence for specificity in the interaction and introduce emerging technologies that enable detailed assessment of protein-GAG interactions. Finally, we address the issue of exploitation of this interaction for therapeutic advantage.

PMID:
15990353
DOI:
10.1016/j.cytogfr.2005.04.006
[Indexed for MEDLINE]

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