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Bioorg Med Chem Lett. 2005 Aug 1;15(15):3510-3.

Interaction of chiral MS-245 analogs at h5-HT6 receptors.

Author information

1
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.

Abstract

Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptamine 5-HT(6) receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers.

PMID:
15990303
DOI:
10.1016/j.bmcl.2005.05.092
[Indexed for MEDLINE]

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