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Org Lett. 2005 Jul 7;7(14):3049-52.

Ionic liquid as catalyst and reaction medium. The dramatic influence of a task-specific ionic liquid, [bmIm]OH, in Michael addition of active methylene compounds to conjugated ketones, carboxylic esters, and nitriles.

Author information

1
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur. ocbcr@iacs.res.in

Abstract

[reaction: see text] A task-specific ionic liquid, [bmIm]OH, has been introduced as a catalyst and as a reaction medium in Michael addition. Very interestingly, although the addition to alpha,beta-unsaturated ketones proceeds in the usual way, giving the monoaddition products, this ionic liquid always drives the reaction of open-chain 1,3-dicarbonyl compounds with alpha,beta-unsaturated esters and nitriles toward bis-addition to produce exclusively bis-adducts in one stroke.

PMID:
15987202
DOI:
10.1021/ol051004h

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